MLB's no-hitters and perfect games
| Date | Pitcher | Throws | Team | Opponent | IP | Pitches | K | BB | E | Catcher | Umpire | Last out | Time | Score | Notes |
| June 13 2012 | Matt Cain | RHP | San Francisco Giants | Houston Astros | 9 | 125 | 14 | - | - | Buster Posey | Ted Barrett | Jason Castro | 2:36 | 10-0 | Perfect game |
| September 14 2008 | Carlos Zambrano | RHP | Chicago Cubs | Houston Astros | 9 | 110 | 10 | 1 | - | Geovany Soto | Tim Tschida | Darin Erstad | 2:17 | 5-0 | First no-hitter as neutral site (Miller Park in Milwaukee) |
| July 12 1997 | Francisco Cordova | RHP | Pittsburgh Pirates | Houston Astros | 9 | 121 | 10 | 1 | - | Jason Kendall | Tom Hallion | Brad Ausmus | 2:39 | 3-0 | COMBINED: Ricardo Rincon earned with in 10th inning |
| April 30 1969 | Jim Maloney | RHP | Cincinnati Reds | Houston Astros | 9 | - | 13 | 5 | - | Johnny Bench | Frank Secory | Doug Rader | 2:28 | 10-0 | - |
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